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With the concept a more quick cell cycle is often a vital element of pluripotency, reprogramming effectiveness may be improved. Strategies for enhancing pluripotency via manipulation of cell cycle regulators involve: overexpression of Cyclin D/Cdk4, phosphorylation of Sox2 at S39 and S253, overexpression of Cyclin A and Cyclin E, knockdown of Rb, a

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